D46.20
Refractory anemia with excess of blasts, unspecified
Clinical Classification Guidelines
Inclusion Terms
- RAEB NOS
Medical Intelligence & Overview
Refractory anemia with excess of blasts, unspecified (RAEB NOS), is a type of blood disorder characterized by abnormal development of red blood cells in the bone marrow. It is considered a myelodysplastic syndrome, a group of conditions where the bone marrow produces insufficient and abnormal blood cells. RAEB NOS is marked by an increased number of immature blood cells, or blasts, in the marrow, which can sometimes progress to leukemia. This disorder primarily affects adults and requires ongoing medical monitoring.
Causes & Symptoms
Clinical Causes: Genetic mutations affecting bone marrow cell development Previous exposure to chemotherapy or radiation therapy Environmental factors such as exposure to certain chemicals or toxins Inherited genetic conditions Progression of other myelodysplastic syndromes
Key Symptoms: Fatigue and weakness due to anemia Shortness of breath during physical activity Unusual bruising or bleeding caused by low platelet levels Increased susceptibility to infections due to low white blood cells Pale skin Weight loss and lack of appetite Fever or night sweats in some cases
Diagnostic & Treatment
Diagnosis Path: Diagnosis of RAEB NOS involves a combination of blood tests and bone marrow examination. Blood tests may reveal anemia and abnormal blood cell counts. A bone marrow biopsy provides a detailed view of cell development and shows an increased proportion of blasts. Additional tests, such as cytogenetic analysis, can identify genetic abnormalities that help confirm the diagnosis and guide treatment planning.
Treatment Protocols: Treatment strategies focus on managing symptoms, preventing complications, and addressing the underlying disorder. These may include:
Clinical Advice & FAQs
Billing Guidance
Is D46.20 a billable ICD-10 code?
Yes, D46.20 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D46.20?
Clinical documentation must specify the nature of Refractory anemia with excess of blasts, unspecified and any associated comorbidities for accurate reporting.
Cite this Clinical Reference