C84.7A
Anaplastic large cell lymphoma, ALK-negative, breast
Clinical Classification Guidelines
Use Additional Code
- code to identify:
- breast implant status (Z98.82)
- personal history of breast implant removal (Z98.86)
Inclusion Terms
- Breast implant associated anaplastic large cell lymphoma (BIA-ALCL)
Medical Intelligence & Overview
Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma, which is a cancer originating in the immune system's lymphocytes. When this lymphoma develops in the breast and is ALK-negative, it means that the genetic marker ALK (anaplastic lymphoma kinase) is not present. This specific subtype is also associated with breast implants, earning the name breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). Though uncommon, awareness of this condition is important for individuals with breast implants to recognize potential symptoms and understand potential risks.
Causes & Symptoms
Clinical Causes: Presence of textured breast implants, as they have been linked to increased risk of BIA-ALCL Chronic inflammation or immune response related to implants Unknown factors that may contribute to lymphocyte transformation into lymphoma cells Possible genetic predispositions, though specific genetic factors are not well established
Key Symptoms: Swelling or fluid buildup around the breast implant (seroma) A lump or mass in the breast or scar tissue Pain or tenderness in the breast area Change in the shape or size of the breast Skin changes, such as redness or dimpling In some cases, systemic symptoms like fever or weight loss
Diagnostic & Treatment
Diagnosis Path: Physical examination to check for swelling, lumps, or other abnormalities Imaging tests such as ultrasound, MRI, or mammography to evaluate the breast tissue and implant site Aspiration of fluid around the implant (if present) for cytological examination to detect lymphoma cells Biopsy of any suspicious tissue or mass to confirm the presence of lymphoma cells and determine subtype Immunohistochemistry tests to determine ALK status and other markers Additional blood tests or scans to ascertain if the disease has spread
Treatment Protocols: Surgical removal of the affected implant and surrounding scar tissue (capsulectomy) Chemotherapy, particularly targeted therapies tailored for lymphoma Radiation therapy in cases with localized disease Immunotherapy options, in some scenarios, to stimulate the immune response against lymphoma cells Multidisciplinary care involving oncologists, surgeons, and radiologists to determine the best treatment plan
Clinical Advice & FAQs
Billing Guidance
Is C84.7A a billable ICD-10 code?
Yes, C84.7A is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C84.7A?
Clinical documentation must specify the nature of Anaplastic large cell lymphoma, ALK-negative, breast and any associated comorbidities for accurate reporting.
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