C84.78
Anaplastic large cell lymphoma, ALK-negative, lymph nodes of multiple sites
Clinical Classification Guidelines
Medical Intelligence & Overview
Anaplastic large cell lymphoma, ALK-negative, is a rare type of non-Hodgkin lymphoma that originates in the lymphatic system. It involves the abnormal growth of lymphocytes, a type of white blood cell crucial for immune defense. This specific subtype is characterized by the absence of the anaplastic lymphoma kinase (ALK) gene rearrangements, which affects how the disease progresses and responds to treatment. Typically, this lymphoma affects multiple lymph node groups throughout the body, making it a complex condition to manage and treat effectively.
Causes & Symptoms
Clinical Causes: Genetic mutations that lead to uncontrolled lymphocyte growth. Possible environmental exposures, although specific causes are not well established. Weakened immune system, which can be due to underlying health issues or immunosuppressive therapies. Family history of lymphomas or related lymphatic diseases, which may increase susceptibility.
Key Symptoms: Swollen and painless lymph nodes, often in the neck, armpits, or groin. Fever that persists over time without obvious infection. Unintentional weight loss and loss of appetite. Night sweats, especially severe and frequent. Fatigue or weakness that interferes with daily activities. Possible symptoms depending on affected organs, such as cough or chest pain if thoracic lymph nodes are involved.
Diagnostic & Treatment
Diagnosis Path: Diagnosing ALK-negative anaplastic large cell lymphoma typically involves a combination of procedures:
Treatment Protocols: Treatment strategies aim to eliminate malignant cells and manage symptoms, often involving a multidisciplinary approach:
Clinical Advice & FAQs
Billing Guidance
Is C84.78 a billable ICD-10 code?
Yes, C84.78 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C84.78?
Clinical documentation must specify the nature of Anaplastic large cell lymphoma, ALK-negative, lymph nodes of multiple sites and any associated comorbidities for accurate reporting.
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