C84.6
Anaplastic large cell lymphoma, ALK-positive
Clinical Classification Guidelines
Inclusion Terms
- Anaplastic large cell lymphoma, CD30-positive
Medical Intelligence & Overview
Anaplastic large cell lymphoma, ALK-positive, is a rare type of non-Hodgkin lymphoma that originates in the lymphatic system. It is characterized by the abnormal growth of large lymphocytes and is distinguished by the presence of the anaplastic lymphoma kinase (ALK) protein. This form of lymphoma typically affects children and young adults but can occur in people of any age. Early diagnosis and treatment are crucial for managing the disease effectively.
Causes & Symptoms
Clinical Causes: Genetic mutations leading to abnormal ALK gene expression Chromosomal translocations involving the ALK gene, most notably the t(2;5)(p23;q35) translocation No clear environmental or infectious causes have been identified, but genetic alterations play a pivotal role Potential familial predisposition, although rare
Key Symptoms: Swollen lymph nodes, often painless and persistent Fever that may come and go Unexplained weight loss Night sweats Fatigue and weakness Skin rashes or nodules (less common) Pain or swelling in the abdomen or chest (if lymph nodes are enlarged in these areas)
Diagnostic & Treatment
Diagnosis Path: Diagnosing anaplastic large cell lymphoma, ALK-positive, involves a combination of clinical evaluation and laboratory tests. Examinations typically include:
Treatment Protocols: Treatment strategies aim to destroy lymphoma cells and manage symptoms. Approaches often involve a combination of therapies:
Clinical Advice & FAQs
Billing Guidance
Is C84.6 a billable ICD-10 code?
Yes, C84.6 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C84.6?
Clinical documentation must specify the nature of Anaplastic large cell lymphoma, ALK-positive and any associated comorbidities for accurate reporting.
Cite this Clinical Reference