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  3. Ch. D50-D89
  4. Sec. D80-D89
  5. Category D89
Category D89

Other disorders involving the immune mechanism, not elsewhere classified

Clinical Classification Guidelines

Specific Diagnosis Codes

Polyclonal hypergammaglobulinemia
D89.0
Cryoglobulinemia
D89.1
Hypergammaglobulinemia, unspecified
D89.2
Immune reconstitution syndrome
D89.3
Mast cell activation syndrome and related disorders
D89.4
Mast cell activation, unspecified
D89.40
Monoclonal mast cell activation syndrome
D89.41
Idiopathic mast cell activation syndrome
D89.42
Secondary mast cell activation
D89.43
Hereditary alpha tryptasemia
D89.44
Other mast cell activation disorder
D89.49
Other specified disorders involving the immune mechanism, not elsewhere classified
D89.8
Graft-versus-host disease
D89.81
Acute graft-versus-host disease
D89.810
Chronic graft-versus-host disease
D89.811
Acute on chronic graft-versus-host disease
D89.812
Graft-versus-host disease, unspecified
D89.813
Autoimmune lymphoproliferative syndrome [ALPS]
D89.82
Cytokine release syndrome
D89.83
Cytokine release syndrome, grade 1
D89.831
Cytokine release syndrome, grade 2
D89.832
Cytokine release syndrome, grade 3
D89.833
Cytokine release syndrome, grade 4
D89.834
Cytokine release syndrome, grade 5
D89.835
Cytokine release syndrome, grade unspecified
D89.839
IgG4-related disease
D89.84
Other specified disorders involving the immune mechanism, not elsewhere classified
D89.89
Disorder involving the immune mechanism, unspecified
D89.9
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Data updated for October 2025 release.

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