C82.58
Diffuse follicle center lymphoma, lymph nodes of multiple sites
Clinical Classification Guidelines
Medical Intelligence & Overview
Diffuse follicle center lymphoma is a type of non-Hodgkin lymphoma that originates in the lymphatic system, specifically within the follicle centers of lymph nodes. This condition is characterized by the abnormal growth of lymphoid tissue across multiple lymph node regions, leading to widespread lymphatic involvement. The disease typically affects adults and can involve various lymphatic tissues including the neck, armpits, abdomen, and pelvis. Recognizing the signs and understanding the nature of this lymphoma are important steps in seeking medical evaluation and management.
Causes & Symptoms
Clinical Causes: Genetic mutations impacting lymphocyte development and function Immunologic factors that weaken the immune response Environmental exposures, such as certain chemicals or radiation Infections that are associated with lymphomas, like Epstein-Barr virus (EBV), though less common in follicle center lymphomas
Key Symptoms: Swelling or painless lumps in multiple lymph nodes, commonly in the neck, armpits, or groin Unintentional weight loss Persistent fatigue and weakness Fever that comes and goes Night sweats, often severe enough to disrupt sleep Abdominal discomfort or pain if lymph nodes are enlarged in the abdomen Itching or skin changes in some cases
Diagnostic & Treatment
Diagnosis Path: Lymph node biopsy: A sample of affected tissue is examined microscopically to confirm lymphoma and determine its specific type Imaging studies: CT scans, PET scans, or MRI to identify the extent and spread of the disease Blood tests: To evaluate overall health and organ function Bone marrow biopsy: Sometimes necessary to check for involvement of the marrow
Treatment Protocols: Chemotherapy: Often using regimens that target rapidly dividing lymphoid cells Immunotherapy: Such as monoclonal antibodies like rituximab that help the immune system identify and attack lymphoma cells Radiation therapy: Used in localized disease or to reduce symptoms Targeted therapies: Emerging options focused on specific molecular features of the lymphoma Stem cell transplant: Considered in select cases, particularly if initial treatments are not effective
Clinical Advice & FAQs
Billing Guidance
Is C82.58 a billable ICD-10 code?
Yes, C82.58 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C82.58?
Clinical documentation must specify the nature of Diffuse follicle center lymphoma, lymph nodes of multiple sites and any associated comorbidities for accurate reporting.
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