ICD-10-PCS Billable Code

3E05317

Introduction Peripheral Artery to Other Thrombolytic with Thrombolytic, Percutaneous Approach

Procedural Specifications

Clinical Axis Detail Definition
Section3 Administration
Body SystemE Physiological Systems and Anatomical Regions
Operation0 Introduction
Body Part5 Peripheral Artery
Approach3 Percutaneous
Device1 Thrombolytic
Qualifier7 Other Thrombolytic

Operation Definition

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

Procedure Overview

Introduction covers putting a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance into or onto a body region, other than blood or blood products, which fall under Transfusion instead. This wide-ranging family includes things like injecting anesthesia, infusing chemotherapy, instilling contrast for imaging, delivering anti-infective medications, or providing nutritional formula through a feeding route.

Because it spans so many substance types and delivery sites, this is one of the most frequently used families in the Administration section. A patient might encounter it during an epidural injection, a course of intravenous antibiotics, contrast dye given before a CT scan, or tube feeding after surgery; each represents a substance being placed into the body to achieve a specific therapeutic or diagnostic goal rather than a physical alteration of tissue.

Anatomy & Axis Detail

Peripheral Artery

A peripheral artery, such as the radial or femoral artery, may be accessed to introduce substances directly into the arterial circulation, including diagnostic contrast for angiography or, less commonly, medications intended for localized regional effect. Arterial introduction differs fundamentally from venous administration because the substance enters at high pressure and travels directly to the capillary beds of downstream tissue without first passing through the pulmonary circulation, which can concentrate effects in a targeted vascular territory. This route requires careful technique given the higher pressure and bleeding risk associated with arterial puncture compared with venous access. Documentation should specify the substance introduced and confirm arterial rather than venous placement, since the two routes carry distinct clinical purposes, risks, and coding implications.

Approach: Percutaneous

In Administration, Percutaneous denotes a substance delivered by needle injection through the skin, such as an intramuscular or subcutaneous injection, without cutting or scope guidance. It differs from External, where the substance is applied to the skin surface itself, and from Via Natural or Artificial Opening, where it is introduced through an orifice rather than through a puncture.

Substance: Thrombolytic

Thrombolytic covers administration of a substance intended to dissolve an existing blood clot, such as tissue plasminogen activator given in acute ischemic stroke, pulmonary embolism, or myocardial infarction. It is distinguished from Platelet Inhibitor, which prevents new clot formation by blocking platelet aggregation rather than breaking down an established clot, and from Antiarrhythmic, which addresses heart rhythm rather than clot burden.

Qualifier: Other Thrombolytic

A residual qualifier for thrombolytic agents used to dissolve blood clots, such as those given in acute stroke or pulmonary embolism, when the specific drug is not otherwise named in Administration's qualifier list. It is distinguished from Recombinant Human-activated Protein C, which acts on coagulation pathways differently and has its own dedicated value.

Coding & Documentation

Correct code assignment depends on identifying three things from the documentation: the substance given, matched to the correct qualifier value; the specific body region or route receiving it; and the approach used, such as percutaneous injection or an existing catheter. Physician orders and medication administration records are the primary support. The most common errors involve selecting an imprecise substance qualifier, for example coding a general anti-infective when the documentation specifies a particular drug category with its own value, or misidentifying the body region when a substance is delivered systemically versus locally, such as an intra-articular injection versus an intravenous one.

Commonly Confused With

This family is easily confused with Transfusion, but any blood or blood product is excluded here and must be coded under Transfusion instead, regardless of how it is delivered. It is also confused with routine medication administration that some facilities do not code separately when it is considered standard nursing care rather than a notable procedural event; coders should apply their facility's guidelines to determine which introductions rise to the level of a codable procedure.