T39.393

Clinical Causes: Accidental overdose, often due to miscalculating the dose Intentional overdose as part of self-harm or suicide attempts Assault involving the administration of NSAIDs without consent Misuse during sports or recreational activities Medication errors, such as confusion between pills or incorrect dosing instructions

Key Symptoms: Gastrointestinal symptoms, including nausea, vomiting, abdominal pain, or bleeding Dizziness or lightheadedness Headaches or confusion Signs of kidney impairment such as decreased urine output or swelling Allergic reactions, including rash, itching, or swelling Lethargy and weakness in severe cases Potential cardiovascular issues, like increased blood pressure

Diagnosis Path: Diagnosis of NSAID poisoning involves a combination of medical history evaluation, physical examination, and laboratory tests. Healthcare providers may perform blood tests to assess kidney function, blood counts, and specific drug levels. Urinalysis can help detect signs of kidney damage or bleeding. In cases of suspected assault, obtaining detailed information about the circumstances and substances involved is important. Imaging studies are rarely necessary but may be used if complications such as gastrointestinal perforation are suspected.

Treatment Protocols: Management of NSAID poisoning depends on the severity and timing of ingestion. Common approaches include: - Supportive care to maintain airway, breathing, and circulation - Activated charcoal administration to reduce absorption if the ingestion was recent - Intravenous fluids to support kidney function and prevent dehydration - Medications to control symptoms, such as antiemetics for nausea - Monitoring kidney function and blood parameters regularly - In severe cases, hospitalization may be necessary for advanced interventions, including dialysis It's important to contact healthcare providers promptly if NSAID overdose is suspected, especially in cases involving assault, to ensure appropriate treatment and prevent complications.