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2. ICD-10 Codes
3. Chapter - R00-R99
4. Section - R50-R69
5. Category - R65
6. R65.21

R65.21 - Severe sepsis with septic shock

• Applicable to Severe sepsis with septic shock
• The 2025 edition of ICD10-CM R65.21 became effective on October 1, 2024.
• This is the American ICD10-CM version of R65.21 - other international versions of ICD10 R65.21 may differ.
• R65.21 is a Billable / Specific ICD10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

The following codes above R65.21 contain annotation back-references that may be applicable to R65.21:

• Chapter: R00-R99 - Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
• Section: R50-R69 - General symptoms and signs
• Category: R65 - Symptoms and signs specifically associated with systemic inflammation and infection

Browse other similar CM codes:

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.