C92.40
Acute promyelocytic leukemia, not having achieved remission
Clinical Classification Guidelines
Inclusion Terms
- Acute promyelocytic leukemia with failed remission
- Acute promyelocytic leukemia NOS
Medical Intelligence & Overview
ICD-10 code C92.40 refers to a specific type of acute myeloid leukemia (AML) called acute promyelocytic leukemia (APL) that has not responded to treatment and has failed to reach remission. This condition is characterized by the rapid growth of abnormal promyelocytes, a type of immature white blood cell. Recognizing this diagnosis is important for healthcare providers to determine appropriate therapeutic strategies and to understand the severity of the disease. APL is a rare and aggressive blood cancer that requires prompt medical attention, especially when remission has not been achieved.
Causes & Symptoms
Clinical Causes: Genetic mutations, most notably the t(15;17) translocation involving the PML and RARA genes Previous exposure to chemotherapy or radiation therapy Inherited genetic predispositions, although rare Environmental factors, though specific external causes are not well understood
Key Symptoms: Fever and night sweats Unexplained weight loss Fatigue and weakness Bleeding and easy bruising Painless lumps or swelling due to tissue infiltration Shortness of breath or bleeding episodes Petechiae — small purple or red spots on the skin Frequent infections due to lowered healthy white blood cells
Diagnostic & Treatment
Diagnosis Path: - Additional tests may include complete blood count (CBC), coagulation profile, and imaging studies to assess the disease extent.
Treatment Protocols: - In cases of treatment failure, alternative therapies or clinical trials may be considered.
Clinical Advice & FAQs
Billing Guidance
Is C92.40 a billable ICD-10 code?
Yes, C92.40 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C92.40?
Clinical documentation must specify the nature of Acute promyelocytic leukemia, not having achieved remission and any associated comorbidities for accurate reporting.
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