O46.011
Antepartum hemorrhage with afibrinogenemia, first trimester
Clinical Classification Guidelines
Medical Intelligence & Overview
Antepartum hemorrhage refers to bleeding that occurs during pregnancy before the onset of labor. When this bleeding is associated with afibrinogenemia—a rare blood disorder characterized by the absence or extremely low levels of fibrinogen, a protein essential for blood clotting—it presents unique challenges. The specific ICD-10 Code O46.011 describes cases where pregnant women in their first trimester experience significant bleeding coupled with afibrinogenemia. Recognizing the signs, understanding causes, and available treatments are crucial for managing this condition effectively, ensuring the health and safety of both mother and baby.
Causes & Symptoms
Clinical Causes: Inherited genetic mutations affecting fibrinogen production, leading to congenital afibrinogenemia. Acquired conditions such as severe liver disease or vitamin K deficiency, which can impair clotting factor synthesis. Complications from other blood disorders that impact coagulation pathways. Pregnancy-related changes that can exacerbate underlying coagulation issues.
Key Symptoms: Vaginal bleeding during the first trimester. Heavy bleeding that may be difficult to control. Signs of anemia, such as fatigue, weakness, and pallor. Possible signs of placental separation or abnormal placental attachment. In rare cases, symptoms of disseminated intravascular coagulation (DIC), including bleeding from multiple sites and systemic signs.
Diagnostic & Treatment
Diagnosis Path: The diagnosis of antepartum hemorrhage with afibrinogenemia involves a combination of clinical assessment and laboratory tests. Blood tests to evaluate clotting status are essential, including measuring fibrinogen levels. When fibrinogen levels are undetectable or severely low, and bleeding symptoms are present, afibrinogenemia is diagnosed. Additional diagnostic steps may include:
Treatment Protocols: Managing antepartum hemorrhage with afibrinogenemia requires a coordinated approach tailored to the specific needs of the patient. Treatment strategies focus on controlling bleeding, replenishing deficient clotting factors, and monitoring fetal well-being. Common management options include:
Clinical Advice & FAQs
Billing Guidance
Is O46.011 a billable ICD-10 code?
Yes, O46.011 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report O46.011?
Clinical documentation must specify the nature of Antepartum hemorrhage with afibrinogenemia, first trimester and any associated comorbidities for accurate reporting.
Cite this Clinical Reference