D70.4
Cyclic neutropenia
Clinical Classification Guidelines
Inclusion Terms
- Cyclic hematopoiesis
- Periodic neutropenia
Medical Intelligence & Overview
Cyclic neutropenia, also known as periodic hematopoiesis, is a rare blood disorder characterized by regular, cyclical drops in the number of a specific type of white blood cell called neutrophils. Neutrophils play a crucial role in fighting bacterial infections. The condition involves recurring episodes of neutropenia, where neutrophil counts decrease significantly, increasing the risk of infections. These cycles typically occur every few weeks and can last for several days, leading to symptoms that fluctuate over time. Recognizing and understanding cyclic neutropenia is important for managing its episodes and reducing complications.
Causes & Symptoms
Clinical Causes: Genetic mutations affecting neutrophil production Inherited from family members in many cases Disruptions in bone marrow function that regulate blood cell production
Key Symptoms: Recurrent episodes of fever Sore throat and mouth ulcers Increased susceptibility to bacterial infections Swollen lymph nodes Fatigue and weakness during neutropenic episodes Mild to moderate flu-like symptoms Possible skin infections or abscesses
Diagnostic & Treatment
Diagnosis Path: Diagnosis often involves a combination of medical history, physical examinations, and laboratory tests. Blood tests reveal a pattern of decreased neutrophil counts occurring cyclically over a span of weeks. Additional tests, such as bone marrow examination, may be performed to rule out other marrow disorders. Genetic testing can identify mutations associated with the condition, confirming the diagnosis.
Treatment Protocols: Management of cyclic neutropenia focuses on preventing infections and reducing the severity of neutropenic episodes. Strategies include:
Clinical Advice & FAQs
Billing Guidance
Is D70.4 a billable ICD-10 code?
Yes, D70.4 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D70.4?
Clinical documentation must specify the nature of Cyclic neutropenia and any associated comorbidities for accurate reporting.
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