C88.4
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma]
Clinical Classification Guidelines
Inclusion Terms
- Lymphoma of skin-associated lymphoid tissue [SALT-lymphoma]
- Lymphoma of bronchial-associated lymphoid tissue [BALT-lymphoma]
Excludes Type 1
- high malignant (diffuse large B-cell) lymphoma (C83.3-)
Medical Intelligence & Overview
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, commonly known as MALT lymphoma, is a type of slow-growing cancer that originates in the lymphoid tissue associated with mucous membranes. It primarily affects areas such as the stomach, salivary glands, thyroid, lungs, and eyes, but can also develop in other mucosal sites. This lymphoma is distinguished by its unique origin in extranodal sites, outside of the lymph nodes, and its relatively indolent course compared to other lymphomas. Recognizing and diagnosing MALT lymphoma involves understanding its causes, symptoms, diagnosis procedures, and treatment options.
Causes & Symptoms
Clinical Causes: Chronic infections, such as Helicobacter pylori in gastric MALT lymphoma Autoimmune diseases like Sjögren's syndrome or Hashimoto's thyroiditis Long-term inflammation or antigenic stimulation of mucosal tissues Genetic factors and chromosomal abnormalities specific to lymphoma cells Environmental exposures, though less clearly established
Key Symptoms: Persistent swelling or lumps in affected areas Unexplained weight loss Fatigue and weakness Localized pain or discomfort Symptoms related to the specific site involved, such as difficulty swallowing if the throat is affected or breathing issues if the lungs are involved Occasional redness or inflammation in the affected mucosal areas No noticeable symptoms in early stages, often discovered during routine examinations
Diagnostic & Treatment
Diagnosis Path: Diagnosing MALT lymphoma typically involves a combination of clinical evaluations and laboratory investigations. Healthcare providers may perform the following:
Treatment Protocols: Treatment strategies for MALT lymphoma depend on the location, stage, and spread of the disease, with options including:
Clinical Advice & FAQs
Billing Guidance
Is C88.4 a billable ICD-10 code?
Yes, C88.4 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C88.4?
Clinical documentation must specify the nature of Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue [MALT-lymphoma] and any associated comorbidities for accurate reporting.
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