D71.1
Leukocyte adhesion deficiency
Clinical Classification Guidelines
Inclusion Terms
- LAD-I
- LAD-II
- LAD-III
- Leukocyte adhesion deficiency type I
- Leukocyte adhesion deficiency type II
- Leukocyte adhesion deficiency type III
Medical Intelligence & Overview
Leukocyte adhesion deficiency (LAD) is a rare inherited immune system disorder that affects the ability of white blood cells to combat infections effectively. Classified under ICD-10 code D71.1, LAD impairs the normal function of leukocytes (white blood cells), leading to increased susceptibility to bacterial and fungal infections. There are different types of LAD, including LAD-I, LAD-II, and LAD-III, each caused by distinct genetic mutations that disrupt various aspects of white blood cell function.
Causes & Symptoms
Clinical Causes: Genetic mutations inherited in an autosomal recessive pattern Mutations affecting proteins involved in leukocyte adhesion and migration LAD-I: Deficiency of the CD18 protein due to mutations in the ITGB2 gene LAD-II: Defects in the selectin ligand synthesis caused by mutations in the SLC35C1 gene LAD-III: Abnormalities in the signaling pathways of leukocyte integrins, often involving the FERMT3 gene
Key Symptoms: Frequent and severe bacterial infections, especially of the skin, mouth, and respiratory tract Poor wound healing and delayed healing of cuts and scratches Recurrent abscesses and skin infections Delayed umbilical cord separation beyond the typical 2-3 weeks Susceptibility to fungal infections in some cases Absence or low levels of pus formation despite infection
Diagnostic & Treatment
Diagnosis Path: Diagnosis of LAD involves a combination of clinical evaluation and laboratory testing, including:
Treatment Protocols: While there is no definitive cure for LAD, management aims to prevent infections and improve quality of life. Treatments may include:
Clinical Advice & FAQs
Billing Guidance
Is D71.1 a billable ICD-10 code?
Yes, D71.1 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D71.1?
Clinical documentation must specify the nature of Leukocyte adhesion deficiency and any associated comorbidities for accurate reporting.
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