C81.39
Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
Clinical Classification Guidelines
Medical Intelligence & Overview
Lymphocyte depleted Hodgkin lymphoma is a rare and aggressive type of Hodgkin lymphoma characterized by a reduction in lymphocytes within the affected tissues. It primarily involves extranodal sites and solid organs, making it distinct from other Hodgkin lymphoma variants. This subtype tends to occur more frequently in immunocompromised individuals and often presents with more advanced disease. Recognizing and understanding this form of lymphoma is crucial for appropriate diagnosis and management.
Causes & Symptoms
Clinical Causes: The exact cause of lymphocyte depleted Hodgkin lymphoma remains unknown. It is associated with immunodeficiency conditions, such as HIV/AIDS. Previous exposure to radiation or certain chemotherapies may increase risk. Chronic infections and genetic predispositions are considered potential contributing factors.
Key Symptoms: Swollen lymph nodes in the neck, chest, or other areas Unexplained weight loss Fever and night sweats Fatigue and weakness Pain or fullness in affected areas Signs of organ involvement, such as liver or spleen enlargement Symptoms related to tumor mass effect in extranodal sites
Diagnostic & Treatment
Diagnosis Path: Physical examination to identify lymphadenopathy and organ enlargement Biopsy of suspected tissue to observe cellular morphology and architecture Immunohistochemistry testing to detect specific markers (e.g., CD30, CD15) Imaging studies such as CT, PET, or MRI scans to determine extent and spread Laboratory tests including blood counts and organ function assessments Bone marrow biopsy if systemic involvement is suspected
Treatment Protocols: Chemotherapy regimens, often including ABVD or strong alternatives considering disease aggressiveness Radiation therapy targeted at affected areas Stem cell transplantation in advanced or refractory cases Supportive care aimed at managing symptoms and side effects Close monitoring through follow-up imaging and laboratory tests
Clinical Advice & FAQs
Billing Guidance
Is C81.39 a billable ICD-10 code?
Yes, C81.39 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report C81.39?
Clinical documentation must specify the nature of Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites and any associated comorbidities for accurate reporting.
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