C81.07

Clinical Causes: Genetic mutations that affect lymphocytes Infections, particularly with Epstein-Barr Virus (EBV), though this is less common compared to other types of lymphoma Immune system dysregulation, which may contribute to abnormal lymphocyte growth Environmental factors, although specific external causes are not well established

Key Symptoms: Enlarged spleen (splenomegaly), which can cause discomfort or pain in the upper abdomen Swelling of lymph nodes in the neck, armpits, or groin Unexplained weight loss Fever that persists or recurs Night sweats Fatigue or general weakness Frequent infections due to immune system impairment Unexplained anemia or bleeding tendencies

Diagnosis Path: To diagnose nodular lymphocyte-predominant Hodgkin lymphoma of the spleen, doctors may use a combination of tests and procedures, including: - Physical examination focusing on enlarged lymph nodes and spleen - Blood tests to evaluate blood cell counts and overall health - Imaging techniques such as ultrasound, CT scan, or MRI to visualize spleen and lymph nodes - Biopsy of spleen tissue or lymph node to confirm lymphoma type - Immunohistochemistry and molecular studies to identify specific lymphoma markers Accurate diagnosis often requires tissue analysis under the microscope, emphasizing the importance of biopsy procedures.

Treatment Protocols: Treatment options depend on the disease stage and patient health and may include: - Chemotherapy to target cancerous lymphocytes - Immunotherapy to boost the body's ability to fight the lymphoma - Radiation therapy in certain cases to destroy localized cancer cells - Surgical removal of the spleen (splenectomy) in some conditions, though this is less common - Targeted therapies designed for specific molecular features of the lymphoma Because NHLPL affecting the spleen is a rare condition, management is usually coordinated by a team of specialists such as hematologists and oncologists, tailored to individual patient needs.