D84.0
Lymphocyte function antigen-1 [LFA-1] defect
Clinical Classification Guidelines
Medical Intelligence & Overview
A lymphocyte function antigen-1 (LFA-1) defect, classified under ICD-10 code D84.0, is a rare immune system disorder characterized by abnormalities in a specific protein located on the surface of white blood cells. LFA-1 plays a vital role in immune response, helping immune cells to stick to each other and to other cells, facilitating immune surveillance and defense against infections. Defects in LFA-1 can impair these processes, leading to increased vulnerability to infections and immune-related complications.
Causes & Symptoms
Clinical Causes: Genetic mutations affecting the gene responsible for producing LFA-1 Inherited in an autosomal recessive pattern, meaning both copies of the gene in each cell have to be defective Potentially associated with other immune system abnormalities
Key Symptoms: Recurrent bacterial, viral, or fungal infections Frequent episodes of skin infections, including abscesses or cellulitis Difficulty healing wounds or skin lesions Persistent lymphadenopathy (enlarged lymph nodes) Increased susceptibility to certain viruses, such as Epstein-Barr virus or cytomegalovirus Potential inflammatory complications unresolved by standard immune responses
Diagnostic & Treatment
Diagnosis Path: The diagnosis of a LFA-1 defect involves a combination of clinical assessment and laboratory testing:
Treatment Protocols: There is no definitive cure for a LFA-1 defect; management focuses on controlling infections and supporting immune function:
Clinical Advice & FAQs
Billing Guidance
Is D84.0 a billable ICD-10 code?
Yes, D84.0 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D84.0?
Clinical documentation must specify the nature of Lymphocyte function antigen-1 [LFA-1] defect and any associated comorbidities for accurate reporting.
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