C51.2

Clinical Causes: Genetic mutations leading to abnormal cell growth Chronic inflammation or irritation of the clitoral tissue Human papillomavirus (HPV) infection, which is associated with some genital cancers History of other gynecological cancers Exposure to carcinogenic substances or environmental factors

Key Symptoms: A noticeable lump or mass on or near the clitoris Persistent pain or discomfort in the genital area Ulceration or open sore that does not heal Bleeding from the clitoral area unrelated to menstrual cycles Swelling or enlargement of the clitoris Changes in skin texture or color in the affected area Unexplained weight loss or fatigue in advanced cases

Diagnosis Path: Diagnosing a malignant neoplasm of the clitoris involves several steps: - Physical examination to assess any visible or palpable abnormalities - Imaging studies such as ultrasound, MRI, or CT scans to evaluate the extent of the tumor - Biopsy of the suspicious tissue to confirm cancerous cells - Additional tests like pelvic exams and laboratory assessments to rule out metastasis and assess overall health A multidisciplinary approach is often employed to determine the stage and plan effective treatment strategies.

Treatment Protocols: Management of malignant neoplasm of the clitoris typically includes: - Surgical removal of the tumor, which may involve partial or complete removal of the clitoris and surrounding tissues - Radiation therapy to target residual cancer cells - Chemotherapy, particularly in advanced cases or when the cancer has spread - Targeted therapy or immunotherapy may be considered in certain cases based on specific tumor characteristics - Supportive care to address symptoms and maintain quality of life Each treatment plan is tailored to the individual’s health status, stage of the tumor, and personal considerations. Prevention strategies focus on reducing risk factors such as HPV vaccination and regular gynecological examinations, which can aid early detection and improve outcomes.