1. Home
2. ICD-10 Codes
3. Chapter - D50-D89
4. Section - D80-D89
5. Category - D89
6. D89.4

D89.4 - Mast cell activation syndrome and related disorders

• Applicable to Mast cell activation syndrome and related disorders
• The 2025 edition of ICD10-CM D89.4 became effective on October 1, 2024.
• This is the American ICD10-CM version of D89.4 - other international versions of ICD10 D89.4 may differ.
• D89.4 is a Non-Billable / Non-Specific ICD10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
• D89.4 Code should not be used for billing or reimbursement purposes as there are multiple ICD-10 CM codes below it that contain a greater level of detail.

Type 1 Excludes

• aggressive systemic mastocytosis (C96.21)
• congenital cutaneous mastocytosis (Q82.2)
• (non-congenital) cutaneous mastocytosis (D47.01)
• (indolent) systemic mastocytosis (D47.02)
• malignant mast cell neoplasm (C96.2-)
• malignant mastocytoma (C96.29)
• mast cell leukemia (C94.3-)
• mast cell sarcoma (C96.22)
• mastocytoma NOS (D47.09)
• other mast cell neoplasms of uncertain behavior (D47.09)
• systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)

The following codes above D89.4 contain annotation back-references that may be applicable to D89.4:

• Chapter: D50-D89 - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
• Section: D80-D89 - Certain disorders involving the immune mechanism
• Category: D89 - Other disorders involving the immune mechanism, not elsewhere classified

Browse other similar CM codes:

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.