T45.614

Clinical Causes: Accidental overdose of thrombolytic medication Misadministration or incorrect dosing during medical treatment Unintentional ingestion by individuals not authorized to use the medication Use of expired or improperly stored medications leading to toxicity Switching or mixing medications without proper guidance

Key Symptoms: Bleeding or unusual bruising Drop in blood pressure (hypotension) Signs of internal bleeding, such as swelling or pain in the abdomen Prolonged or unexplained bleeding from cuts or gingiva Dizziness or fainting Hemorrhagic stroke symptoms, like sudden weakness or paralysis Anemia symptoms, including pallor and fatigue Nausea or vomiting, sometimes with blood

Diagnosis Path: Diagnosis of poisoning by thrombolytic drugs involves a comprehensive assessment including patient history, medication review, and clinical examination. Healthcare providers may order laboratory tests such as blood counts, coagulation profiles (like PT, aPTT), and imaging studies if internal bleeding is suspected. Identifying the specific cause or substance involved might be challenging when the case is undetermined, requiring careful evaluation to rule out other conditions. In some cases, diagnosis relies on correlating clinical signs with recent medication use and laboratory findings.

Treatment Protocols: Discontinuation of the offending thrombolytic agent Administration of medications to reverse anticoagulation effects, such as transfusions of blood products or specific antidotes if available Supportive care to maintain blood pressure and organ function Monitoring and managing bleeding through repeated laboratory tests Surgical intervention if internal bleeding or hematomas are life-threatening Addressing any underlying conditions that may have contributed to the event Careful follow-up to assess recovery and prevent recurrence