T45.601

Clinical Causes: Accidental ingestion of fibrinolysis-affecting medications, especially in children or individuals with cognitive impairments Incorrect dosing or medication errors by healthcare providers or caregivers Misunderstanding prescriptions or instructions related to these drugs Use of contaminated or improperly labeled medications Self-medicating without proper guidance, leading to overdose

Key Symptoms: Unusual bleeding or bruising Blood in urine or stools Unexplained fatigue or weakness Dizziness or fainting spells Headaches that are severe or persistent Signs of internal bleeding, such as abdominal pain or vomiting blood Shortness of breath or rapid heartbeat Swelling or pain at injection sites (if administered via injection)

Diagnosis Path: Diagnosing this type of poisoning involves a comprehensive medical evaluation, including patient history and physical examination. Laboratory tests like blood clotting profiles (e.g., prothrombin time, activated partial thromboplastin time) can reveal bleeding abnormalities. Blood tests may also detect the presence and concentration of the offending drug. Depending on the severity, imaging studies may be required to identify internal bleeding or related complications. Accurate identification of the specific medication involved is crucial to guide treatment.

Treatment Protocols: Discontinuation of the fibrinolysis-affecting medication Administration of blood products, such as fresh frozen plasma or platelets, to restore clotting factors Use of specific reversal agents if available, like antifibrinolytic medications Supportive care to stabilize vital signs and address symptoms Monitoring for ongoing bleeding or clotting abnormalities Addressing the underlying cause of accidental ingestion, including counseling or patient education