D69.1
Qualitative platelet defects
Clinical Classification Guidelines
Inclusion Terms
- Bernard-Soulier [giant platelet] syndrome
- Glanzmann's disease
- Grey platelet syndrome
- Thromboasthenia (hemorrhagic) (hereditary)
- Thrombocytopathy
Excludes Type 1
- hemolytic-uremic syndrome (D59.3-)
Excludes Type 2
- von Willebrand disease (D68.0-)
Medical Intelligence & Overview
Qualitative platelet defects, classified under ICD-10 code D69.1, refer to conditions where platelets, crucial blood components for clotting, are present in normal numbers but do not function properly. These disorders can lead to increased bleeding or bruising sensations, despite adequate platelet counts. They encompass a variety of hereditary disorders, including Bernard-Soulier syndrome, Glanzmann's thrombasthenia, Grey platelet syndrome, and other hereditary thrombocytopathies. These conditions are primarily inherited and can vary significantly in severity and presentation.
Causes & Symptoms
Clinical Causes: Genetic mutations affecting platelet function Inheritance of specific gene defects impacting platelet proteins and receptors Family history of platelet dysfunction disorders Certain acquired conditions that mimic hereditary patterns (less common)
Key Symptoms: Easy bruising and extensive skin discolorations Frequent nosebleeds and bleeding gums Prolonged bleeding after injuries or surgeries Unexplained bleeding episodes, including heavy menstrual periods Potential development of petechiae or small pinpoint hemorrhages on the skin
Diagnostic & Treatment
Diagnosis Path: Complete blood count (CBC) to assess platelet numbers Blood smear analysis to examine platelet appearance Platelet function testing (aggregometry) to evaluate how well platelets clump together and form clots Flow cytometry for identification of specific platelet surface proteins and receptors Genetic testing to identify mutations related to hereditary platelet disorders
Treatment Protocols: Use of antifibrinolytic agents to control bleeding episodes Platelet transfusions during significant hemorrhagic events or before surgical procedures Avoidance of medications that impair platelet function, such as certain NSAIDs Desmopressin (DDAVP) in specific conditions to aid clot formation Genetic counseling for families affected by hereditary disorders Supportive care, including wound management and bleeding precautions
Clinical Advice & FAQs
Billing Guidance
Is D69.1 a billable ICD-10 code?
Yes, D69.1 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D69.1?
Clinical documentation must specify the nature of Qualitative platelet defects and any associated comorbidities for accurate reporting.
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