M06.031

Clinical Causes: Genetic predisposition may increase the likelihood of developing seronegative RA. Environmental factors, such as smoking or exposure to certain pollutants, could contribute. An abnormal immune response where the body mistakenly attacks its joint tissues. Possible triggers include infections or other immune system activators, though exact causes are not fully understood.

Key Symptoms: Persistent pain, especially in the right wrist where the inflammation is localized. Swelling and warmth around the affected joint. Stiffness in the wrist, particularly noticeable in the morning or after periods of inactivity. Reduced range of motion making wrist movements difficult. Fatigue and general feelings of malaise may accompany joint symptoms. Potential redness and tenderness over the joint.

Diagnosis Path: Physical examination focusing on joint swelling, tenderness, and range of motion. Imaging tests like X-rays or ultrasounds to assess joint damage or inflammation. Blood tests to rule out other causes and to check for inflammatory markers such as ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein). Serological tests to confirm the absence of rheumatoid factor (RF) and anti-CCP antibodies, supporting the diagnosis of seronegative RA.

Treatment Protocols: Nonsteroidal anti-inflammatory drugs (NSAIDs) to relieve pain and inflammation. Disease-modifying antirheumatic drugs (DMARDs) to slow disease progression, even in seronegative cases. Biologic agents may be considered if traditional medications are ineffective. Physical therapy to maintain joint flexibility and strength. Occupational therapy to adapt daily activities and protect joints. Lifestyle modifications, such as regular exercise and a balanced diet, can support overall health. Monitoring and regular follow-up to assess disease activity and treatment effectiveness.