E34.50
Androgen insensitivity syndrome, unspecified
Clinical Classification Guidelines
Inclusion Terms
- Androgen insensitivity NOS
Medical Intelligence & Overview
Androgen Insensitivity Syndrome (AIS) is a condition affecting sexual development in people who are genetically male. This syndrome occurs when the body’s tissues are unable to respond to androgens, the hormones responsible for male traits. As a result, individuals with AIS typically have a normal male karyotype (XY chromosomes), but develop physical traits that are usually female, or may have ambiguous genitalia. The specific subtype referenced here is unspecified AIS, which means the precise severity or presentation can vary and may not fit neatly into established categories.
Causes & Symptoms
Clinical Causes: Mutations in the AR gene, which encodes the androgen receptor Genetic alterations that impair the body's ability to respond to androgens Inherited patterns through family genetics, typically autosomal recessive or dominant
Key Symptoms: Lack of or differing development of male secondary sexual characteristics, such as body hair or deepened voice Shallow or blind-ending vagina Absence of a uterus and fallopian tubes due to the presence of undescended testes Undescended or hidden testes present in the abdomen or pelvis Potential development of gynecomastia (enlargement of breast tissue) Normal female breast development during puberty, despite XY chromosomes Ambiguous genitalia at birth in some cases
Diagnostic & Treatment
Diagnosis Path: Diagnosing AIS involves a combination of physical examinations, medical history review, and laboratory tests. Key steps include:
Treatment Protocols: Management of AIS depends on the individual’s specific presentation and needs. Common aspects of treatment include:
Clinical Advice & FAQs
Billing Guidance
Is E34.50 a billable ICD-10 code?
Yes, E34.50 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report E34.50?
Clinical documentation must specify the nature of Androgen insensitivity syndrome, unspecified and any associated comorbidities for accurate reporting.
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