E67.1

Clinical Causes: High intake of carotene-rich foods such as carrots, sweet potatoes, squash, and dark leafy greens over an extended period. Excessive consumption of dietary supplements containing beta-carotene or other carotenoids. Rare metabolic disorders that impair carotene processing, such as hypothyroidism or diabetes mellitus, which can lead to increased levels of carotene in the blood. Certain medications or health conditions that influence fat absorption and metabolism, indirectly affecting carotene levels.

Key Symptoms: Yellow to orange pigmentation of the skin, especially on the palms of the hands and soles of the feet. The discoloration is generally symmetric and does not involve the sclera (the whites of the eyes). Skin discoloration may be more noticeable after consuming a diet rich in carotenoids. Typically, there are no other systemic symptoms associated with hypercarotenemia.

Diagnosis Path: Diagnosis of hypercarotenemia primarily involves clinical evaluation of skin discoloration and dietary history. Blood tests measuring serum carotene levels can confirm elevated carotene concentrations. A healthcare provider may also assess thyroid function and other metabolic parameters to rule out underlying conditions that influence carotene metabolism. In some cases, skin biopsy may be performed, but it is rarely necessary.

Treatment Protocols: The primary approach to managing hypercarotenemia involves dietary modifications. Reducing intake of carotene-rich foods typically results in gradual normalization of skin coloration. Patients are advised to diversify their diet to include a wider range of nutrients and avoid excessive consumption of carotenoid-rich produce or supplements. Monitoring and addressing any underlying metabolic conditions, such as hypothyroidism, can also aid in resolution. Since hypercarotenemia is harmless, treatment mainly focuses on lifestyle adjustments and patient education.