E85.0
Non-neuropathic heredofamilial amyloidosis
Clinical Classification Guidelines
Inclusion Terms
- Hereditary amyloid nephropathy
Excludes Type 2
- Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)
Code Also
- associated disorders, such as:
- autoinflammatory syndromes (M04.-)
Medical Intelligence & Overview
Non-neuropathic heredofamilial amyloidosis, also known as hereditary amyloid nephropathy, is a rare genetic disorder caused by the abnormal buildup of amyloid proteins in the kidneys and other organs. This condition is inherited and can significantly affect kidney function over time. Recognizing its characteristics and potential impact can help in managing and understanding this complex disease.
Causes & Symptoms
Clinical Causes: Genetic mutations passed down from parents Inheriting gene variants that lead to abnormal amyloid protein production Family history of amyloid-related diseases
Key Symptoms: Progressive decrease in kidney function Protein in the urine (proteinuria) Swelling in the legs, ankles, or other parts of the body due to fluid retention High blood pressure Signs of kidney failure in advanced stages
Diagnostic & Treatment
Diagnosis Path: Blood tests to evaluate kidney function and detect abnormal proteins Urinalysis to check for protein loss in urine Genetic testing to identify specific inherited mutations Biopsy of kidney tissue to observe amyloid deposits under a microscope Imaging tests to assess the extent of organ involvement
Treatment Protocols: Medications to control blood pressure and protect kidney function Dietary modifications to reduce kidney workload, such as limiting salt and protein intake Dialysis in cases of advanced kidney failure Investigational therapies aimed at reducing amyloid deposits Genetic counseling for affected individuals and their families
Clinical Advice & FAQs
Billing Guidance
Is E85.0 a billable ICD-10 code?
Yes, E85.0 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report E85.0?
Clinical documentation must specify the nature of Non-neuropathic heredofamilial amyloidosis and any associated comorbidities for accurate reporting.
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