D59.39
Other hemolytic-uremic syndrome
Clinical Classification Guidelines
Use Additional Code
- code, if applicable, for adverse effect to identify drug (T36-T50 with fifth or sixth character 5)
Inclusion Terms
- Atypical (nongenetic) hemolytic uremic syndrome
- Secondary hemolytic-uremic syndrome
Code First
- , if applicable, any associated:
- COVID-19 (U07.1)
- complications of kidney transplant (T86.1-)
- complications of heart transplant (T86.2-)
- complications of liver transplant (T86.4-)
Code Also
- , if applicable, any associated condition, such as:
- hypertensive emergency (I16.1)
- malignant neoplasm (C00-C96)
- systemic lupus erythematosus (M32.-)
Medical Intelligence & Overview
Other Hemolytic-Uremic Syndrome (HUS), classified under ICD-10 code D59.39, refers to a type of syndrome characterized by the destruction of red blood cells, low platelet count, and kidney failure. Unlike typical HUS, which often follows an infection, this form is considered atypical or secondary, usually resulting from different underlying conditions. It is a serious health condition that requires prompt medical attention to prevent permanent organ damage.
Causes & Symptoms
Clinical Causes: Certain infections, such as bacterial infections other than E. coli Autoimmune diseases that cause immune system dysfunction Use of certain medications, including chemotherapy drugs and immunosuppressants Pregnancy-related complications or postpartum issues Underlying genetic disorders affecting the complement system, though these are less common in atypical HUS
Key Symptoms: Decreased urine output or dark-colored urine Swelling in legs, ankles, or other parts of the body Fatigue and weakness due to anemia Paleness or jaundice (yellowing of the skin and eyes) High blood pressure Nausea and vomiting Fever in some cases Bleeding or easy bruising due to low platelet levels
Diagnostic & Treatment
Diagnosis Path: Blood tests to check for anemia, platelet count, and signs of hemolysis Urinalysis to assess kidney function and detect abnormalities Blood tests to evaluate kidney function, such as serum BUN and creatinine levels Tests to identify underlying causes, like bacterial cultures or autoimmune panels Complement system evaluations, especially if atypical HUS is suspected
Treatment Protocols: Plasmapheresis (plasma exchange) to remove harmful antibodies or components Medications to suppress immune responses in cases related to autoimmune conditions Supportive care, such as dialysis, if kidney failure occurs Blood transfusions to treat severe anemia Medication adjustments or discontinuing causative drugs under medical supervision Treating underlying infections or autoimmune conditions contributing to HUS
Clinical Advice & FAQs
Billing Guidance
Is D59.39 a billable ICD-10 code?
Yes, D59.39 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D59.39?
Clinical documentation must specify the nature of Other hemolytic-uremic syndrome and any associated comorbidities for accurate reporting.
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