E88.02
Plasminogen deficiency
Clinical Classification Guidelines
Use Additional Code
- code for associated findings, such as:
- hydrocephalus (G91.4)
- otitis media (H67.-)
- respiratory disorder related to plasminogen deficiency (J99)
Inclusion Terms
- Dysplasminogenemia
- Hypoplasminogenemia
- Type 1 plasminogen deficiency
- Type 2 plasminogen deficiency
Code Also
- , if applicable, ligneous conjunctivitis (H10.51-)
Medical Intelligence & Overview
Plasminogen deficiency is a rare genetic disorder impacting the blood's ability to break down clots properly. It involves insufficient levels or functioning of plasminogen, a crucial protein that helps dissolve blood clots, preventing excessive clotting and promoting healthy blood flow. This condition can lead to the development of abnormal blood clots and skin issues, particularly severe ulcerations. Recognized under various names such as dysplasminogenemia, hypoplasminogenemia, or types 1 and 2 plasminogen deficiency, it highlights the importance of balanced fibrinolytic activity for overall vascular health.
Causes & Symptoms
Clinical Causes: Inherited genetic mutations affecting the PLG gene, which encodes plasminogen Autosomal dominant inheritance pattern in many cases Potential associations with other rare genetic conditions affecting blood clotting and skin health
Key Symptoms: Development of persistent, non-healing skin ulcers, especially on the lips and oral mucosa Formation of ligneous (woody) conjunctivitis characterized by abnormal, thick, fibrin-rich membrane buildup in the eyes Recurrent or unusual blood clots due to impaired clot breakdown Swelling and inflammation in affected tissues Skin lesions that can become infected or ulcerate In severe cases, involvement of other mucous membranes or internal organs
Diagnostic & Treatment
Diagnosis Path: Diagnosis of plasminogen deficiency involves specific blood tests to measure plasminogen levels. Additional laboratory assessments may include genetic testing to identify mutations in the PLG gene, and histopathological examination of tissue samples from skin or mucous membranes showing characteristic fibrin-rich material. Medical history and clinical presentation guide healthcare providers in suspecting and confirming this rare disorder.
Treatment Protocols: Treatment strategies aim to manage symptoms and prevent complications. These may include:
Clinical Advice & FAQs
Billing Guidance
Is E88.02 a billable ICD-10 code?
Yes, E88.02 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report E88.02?
Clinical documentation must specify the nature of Plasminogen deficiency and any associated comorbidities for accurate reporting.
Cite this Clinical Reference