D57.414
Sickle-cell thalassemia, unspecified, with dactylitis
Clinical Classification Guidelines
Medical Intelligence & Overview
Sickle-cell thalassemia with dactylitis is a specific type of blood disorder characterized by abnormal hemoglobin production, leading to distorted red blood cells. This condition combines elements of sickle-cell disease and thalassemia, both inherited blood disorders. Dactylitis, or swelling of the fingers and toes, is a common early sign and manifestation of this condition. Understanding this condition helps in recognizing its symptoms and the importance of medical management.
Causes & Symptoms
Clinical Causes: Inherited genetic mutations affecting hemoglobin production Inheritance of sickle cell gene from one parent and thalassemia gene from another Autosomal recessive inheritance pattern, meaning both parents must carry the gene for a child to be affected
Key Symptoms: Dactylitis: painful swelling of the fingers and toes Chronic anemia leading to fatigue and weakness jaundice or yellowing of the skin and eyes Frequent infections due to compromised immune function Delayed growth and development in children Bone pain or deformities Sensitivity to cold temperatures
Diagnostic & Treatment
Diagnosis Path: Diagnosis involves comprehensive blood tests, including hemoglobin electrophoresis to identify abnormal hemoglobin variants. Additional tests may include complete blood count (CBC), reticulocyte count, and imaging studies to assess bone and tissue involvement. Family history and genetic counseling are essential components of diagnosis to determine inherited patterns.
Treatment Protocols: Hydroxyurea therapy to increase fetal hemoglobin production and reduce sickling episodes Blood transfusions to manage severe anemia and prevent stroke Pain management during sickle-cell crises Antibiotic prophylaxis and immunizations to prevent infections Bone marrow transplants in select cases as a potential cure Regular monitoring by healthcare professionals to detect and treat complications early Supportive care such as nutritional support and physical therapy
Clinical Advice & FAQs
Billing Guidance
Is D57.414 a billable ICD-10 code?
Yes, D57.414 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D57.414?
Clinical documentation must specify the nature of Sickle-cell thalassemia, unspecified, with dactylitis and any associated comorbidities for accurate reporting.
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