D57.214
Sickle-cell/Hb-C disease with dactylitis
Clinical Classification Guidelines
Medical Intelligence & Overview
Sickle-cell/Hb-C disease with dactylitis is a specific type of inherited blood disorder that affects the shape of red blood cells. This condition combines features of sickle-cell disease and hemoglobin C disease, resulting in unique health challenges. One hallmark of this disease is dactylitis, a painful swelling of the fingers and toes caused by blockages in blood flow. Understanding this condition helps in recognizing its signs, causes, and management options.
Causes & Symptoms
Clinical Causes: Inheritance of mutations in the HBB gene that produce abnormal hemoglobin S and C proteins Passing of defective genes from parents to children, following an autosomal recessive inheritance pattern Genetic predisposition to produce abnormal hemoglobin that causes red blood cells to change shape
Key Symptoms: Dactylitis: swelling, pain, and tenderness in the fingers or toes Fatigue due to decreased oxygen delivery to tissues Episodes of pain throughout the body, especially during sickling events Jaundice or yellowing of the skin and eyes Frequent infections due to spleen damage Delayed growth or puberty in children Sudden episodes of severe pain or crises
Diagnostic & Treatment
Diagnosis Path: Hemoglobin electrophoresis: to determine the types and quantities of hemoglobin present Complete blood count (CBC): to assess anemia severity Blood smear: to visualize the shape of red blood cells Genetic testing: for definitive identification of mutations in the HBB gene
Treatment Protocols: Pain management with medications during crises Preventive measures such as vaccination and antibiotic prophylaxis to reduce infection risk Hydroxyurea: a medication that can reduce the frequency of sickling episodes and pain crises Blood transfusions: to treat severe anemia or prevent stroke Bone marrow transplant: a potential cure in selected cases Regular health monitoring and supportive care to address organ damage and other complications
Clinical Advice & FAQs
Billing Guidance
Is D57.214 a billable ICD-10 code?
Yes, D57.214 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D57.214?
Clinical documentation must specify the nature of Sickle-cell/Hb-C disease with dactylitis and any associated comorbidities for accurate reporting.
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