R65.11
Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
Clinical Classification Guidelines
Use Additional Code
- code to identify specific acute organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory failure (J96.0-)
- critical illness myopathy (G72.81)
- critical illness polyneuropathy (G62.81)
- disseminated intravascular coagulopathy [DIC] (D65)
- encephalopathy (metabolic) (septic) (G93.41)
- hepatic failure (K72.0-)
Medical Intelligence & Overview
Systemic Inflammatory Response Syndrome (SIRS) is a serious condition characterized by widespread inflammation throughout the body. When SIRS occurs without the presence of an infection—known as non-infectious SIRS—it can result from various medical situations, such as trauma, burns, or pancreatitis. The condition becomes particularly concerning when it leads to acute organ dysfunction, meaning that vital organs like the kidneys, lungs, or liver start to fail suddenly. Recognizing and understanding this condition is important for timely medical intervention and management.
Causes & Symptoms
Clinical Causes: Severe trauma or physical injury Burns covering a large area of the body Pancreatitis (inflammation of the pancreas) Multiple blood transfusions Surgical procedures or invasive medical interventions Severe physical stress or tissue damage Shock from various causes It can also be associated with other non-infectious inflammatory conditions
Key Symptoms: Fever or abnormal temperature regulation Increased heart rate (tachycardia) Rapid breathing (tachypnea) Low blood pressure (hypotension) Altered mental status, confusion or agitation Signs of organ dysfunction such as decreased urine output, jaundice, or difficulty breathing General malaise or weakness Elevated or decreased white blood cell count
Diagnostic & Treatment
Diagnosis Path: Presence of at least two of the following signs from the systemic inflammatory response criteria: Body temperature above 38°C (100.4°F) or below 36°C (96.8°F) Heart rate greater than 90 beats per minute Respiratory rate greater than 20 breaths per minute or arterial carbon dioxide (PaCO2) less than 32 mm Hg Abnormal white blood cell count, either elevated or decreased Evidence of acute organ dysfunction, such as abnormal kidney or liver function tests, lung impairment, or blood clotting issues
Treatment Protocols: Aggressive fluid management to maintain blood pressure and organ perfusion Use of medications to support blood pressure and heart function Oxygen therapy or mechanical ventilation if respiratory failure occurs Monitoring and managing organ-specific issues, such as dialysis for kidney failure Addressing the underlying cause or trigger—such as minimizing tissue injury or managing inflammation Nutritional support to aid recovery In some cases, corticosteroids or other anti-inflammatory agents may be used under medical supervision
Clinical Advice & FAQs
Billing Guidance
Is R65.11 a billable ICD-10 code?
Yes, R65.11 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report R65.11?
Clinical documentation must specify the nature of Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction and any associated comorbidities for accurate reporting.
Cite this Clinical Reference