T43.20

Clinical Causes: Accidental overdose of antidepressants Intentional overdose in cases of self-harm Misuse or recreational use of antidepressants Inappropriate dosing, either underdosing or overdosing Sensitivity or allergic reactions to a specific antidepressant Drug interactions with other medications that increase toxicity

Key Symptoms: Nausea and vomiting Dizziness or lightheadedness Sleep disturbances or drowsiness Agitation or confusion Rapid or irregular heartbeat Muscle weakness or tremors Seizures in severe cases Respiratory depression Loss of consciousness or coma in extreme situations

Diagnosis Path: Diagnosis involves a thorough medical history review, including medication intake and timing. Physical examination focuses on neurological and cardiovascular status. Laboratory tests such as blood levels of antidepressants, blood gas analysis, and kidney and liver function tests may be conducted to assess the severity of poisoning and identify specific substances involved. Toxicology screens can help detect other concurrent substances that might complicate the clinical picture.

Treatment Protocols: Treatment strategies depend on the severity of the poisoning and the specific antidepressant involved. Common approaches include: - Monitoring vital signs closely in a medical setting - Activated charcoal administration to absorb toxins in early stages - Administering antidotes if available and appropriate - Supportive care such as IV fluids, oxygen therapy, and seizure management - Gastric lavage in certain cases within a specific time frame after ingestion - Continuous cardiac monitoring to detect and manage arrhythmias Severe cases might require intensive care, and treatment will be individualized based on patient condition. Counseling and mental health support are essential components to prevent future incidents, alongside therapy to address underlying mental health issues.