T43.214

Clinical Causes: Accidental overdose due to miscalculation or mistaken ingestion Intentional misuse or overdose in suicide attempts Combination with other medications or substances that increase toxicity Improper storage or access to medications, especially around children or vulnerable individuals

Key Symptoms: Nausea and vomiting Dizziness or lightheadedness Rapid heartbeat (tachycardia) Increased blood pressure Agitation or restlessness Confusion or hallucinations Seizures Serotonin syndrome symptoms such as tremors, sweating, and muscle rigidity Loss of consciousness or coma in severe cases

Diagnosis Path: Diagnosing poisoning by SSNRIs generally involves a thorough medical history, including recent medication ingestion, along with physical examinations. Healthcare providers may perform blood tests to detect the presence and levels of the medication in the bloodstream. Additional assessments, such as electrocardiograms (ECGs), can help evaluate cardiac effects. In cases suspected of serotonin syndrome, specific diagnostic criteria are used based on the observed symptoms.

Treatment Protocols: Treatment strategies for poisoning by SSNRIs focus on stabilizing the individual's vital signs and preventing further absorption of the drug. Common interventions include: - Administration of activated charcoal to bind the medication in the gastrointestinal tract, if the ingestion was recent - Supportive care such as intravenous fluids to maintain hydration - Medications to manage symptoms like heart rate and blood pressure abnormalities - Monitoring for and treating serotonin syndrome, which may involve drugs like cyproheptadine - In severe cases, hospitalization in an intensive care setting may be necessary, and advanced measures like mechanical ventilation or hemodialysis could be considered It is essential for anyone suspected of SSNRI poisoning to receive prompt medical attention to mitigate risks and complications.