D81.32
Adenosine deaminase 2 deficiency
Clinical Classification Guidelines
Inclusion Terms
- ADA2 deficiency
- Adenosine deaminase deficiency type 2
Code Also
- , if applicable, any associated manifestations, such as:
- polyarteritis nodosa (M30.0)
- stroke (I63.-)
Medical Intelligence & Overview
Adenosine deaminase 2 deficiency, also known as ADA2 deficiency, is a rare genetic disorder that affects the immune system and blood vessels. It is characterized by a variety of symptoms, including inflammation, blood vessel problems, and immune system issues. This condition falls under the ICD-10 code D81.32 and is important for accurate diagnosis and management.
Causes & Symptoms
Clinical Causes: Genetic mutation in the ADA2 gene Inherited in an autosomal recessive manner, meaning a person needs to inherit two copies of the mutated gene to develop the condition Lack of functional ADA2 enzyme, leading to increased inflammation and vascular problems
Key Symptoms: Frequent or severe inflammation Vascular issues such as blood vessel inflammation, leading to skin rashes, foot ulcers, or other circulatory complications Immune system irregularities including recurrent infections Joint pain and swelling Lupus-like symptoms, such as fatigue and skin rashes Fever episodes Lymphadenopathy (enlarged lymph nodes)
Diagnostic & Treatment
Diagnosis Path: Genetic testing to identify mutations in the ADA2 gene Measurement of ADA2 enzyme activity levels in blood samples Blood tests to assess inflammation and immune function Imaging studies if vascular involvement is suspected
Treatment Protocols: Immunosuppressive medications to control inflammation Biologic therapies targeting specific immune pathways Supportive care for vascular symptoms, such as wound care for ulcers Regular monitoring by healthcare providers specialized in immunology and rheumatology In some cases, bone marrow or stem cell transplant may be considered
Clinical Advice & FAQs
Billing Guidance
Is D81.32 a billable ICD-10 code?
Yes, D81.32 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D81.32?
Clinical documentation must specify the nature of Adenosine deaminase 2 deficiency and any associated comorbidities for accurate reporting.
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