D81.39
Other adenosine deaminase deficiency
Clinical Classification Guidelines
Inclusion Terms
- Adenosine deaminase [ADA] deficiency type 1, NOS
- Adenosine deaminase [ADA] deficiency type 1, without SCID
- Adenosine deaminase [ADA] deficiency type 1, without severe combined immunodeficiency
- Partial ADA deficiency (type 1)
- Partial adenosine deaminase deficiency (type 1)
Medical Intelligence & Overview
Other adenosine deaminase deficiency (ICD-10 Code D81.39) is a rare genetic disorder affecting the immune system. It involves a deficiency in the enzyme adenosine deaminase (ADA), which plays a critical role in the function and development of immune cells. Unlike complete ADA deficiency, which can lead to severe combined immunodeficiency (SCID), this form typically results in partial immune system impairment without full-blown SCID. Recognizing this condition is important for understanding its impact on immune health and potential treatment options.
Causes & Symptoms
Clinical Causes: Inherited genetic mutations affecting the ADA gene Autosomal recessive inheritance pattern Presence of mutations that result in partial enzyme activity No known environmental factors directly cause the condition
Key Symptoms: Increased susceptibility to infections, especially frequent respiratory infections Recurrent bacterial or viral infections Delayed growth and development in children Persistent diarrhea or other gastrointestinal issues In some cases, immune system functions are mildly compromised, leading to less severe symptoms
Diagnostic & Treatment
Diagnosis Path: • Immunological assessments to evaluate immune cell function and counts
Treatment Protocols: Regular monitoring of immune function and infection risk Use of antibiotics or antivirals to treat or prevent infections Immunoglobulin replacement therapy in some cases Enzyme replacement therapy, if available and appropriate Haematopoietic stem cell transplantation in severe cases
Clinical Advice & FAQs
Billing Guidance
Is D81.39 a billable ICD-10 code?
Yes, D81.39 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D81.39?
Clinical documentation must specify the nature of Other adenosine deaminase deficiency and any associated comorbidities for accurate reporting.
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