D81.3
Adenosine deaminase [ADA] deficiency
Clinical Classification Guidelines
Medical Intelligence & Overview
Adenosine deaminase deficiency is a rare genetic disorder that affects the immune system. It is classified under ICD-10 code D81.3. This condition interferes with the body's ability to fight infections, leading to increased susceptibility to various illnesses. The deficiency results from mutations in the ADA gene, which impairs the body's ability to produce the enzyme adenosine deaminase, crucial for the development and function of immune cells, especially lymphocytes.
Causes & Symptoms
Clinical Causes: Inherited genetic mutation in the ADA gene Autosomal recessive inheritance pattern, meaning a child needs to inherit two copies of the mutated gene, one from each parent, to develop the disorder Certain populations with higher carrier rates due to genetic factors
Key Symptoms: Severe or recurrent infections, such as pneumonia, meningitis, or skin infections Failure to thrive in infants and young children Persistent diarrhea Enlarged liver and spleen (hepatosplenomegaly) Skin rashes or eczema Chronic diarrhea leading to weight loss Potential neurological symptoms, like developmental delays or seizures in some cases
Diagnostic & Treatment
Diagnosis Path: Diagnosing ADA deficiency involves a combination of clinical assessments and laboratory tests. Key diagnostic steps include:
Treatment Protocols: Treatment options for ADA deficiency focus on managing symptoms and improving immune function. Common approaches include:
Clinical Advice & FAQs
Billing Guidance
Is D81.3 a billable ICD-10 code?
Yes, D81.3 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D81.3?
Clinical documentation must specify the nature of Adenosine deaminase [ADA] deficiency and any associated comorbidities for accurate reporting.
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