D68.2
Hereditary deficiency of other clotting factors
Clinical Classification Guidelines
Inclusion Terms
- AC globulin deficiency
- Congenital afibrinogenemia
- Deficiency of factor I [fibrinogen]
- Deficiency of factor II [prothrombin]
- Deficiency of factor V [labile]
- Deficiency of factor VII [stable]
- Deficiency of factor X [Stuart-Prower]
- Deficiency of factor XII [Hageman]
- Deficiency of factor XIII [fibrin stabilizing]
- Dysfibrinogenemia (congenital)
- Hypoproconvertinemia
- Owren's disease
- Proaccelerin deficiency
Medical Intelligence & Overview
Hereditary deficiency of other clotting factors refers to a group of rare genetic disorders where the body produces insufficient amounts of certain proteins essential for blood clotting. These deficiencies can lead to bleeding tendencies and pose challenges for preventing and controlling bleeding episodes. The condition covers a variety of specific clotting factor deficiencies, including afibrinogenemia, prothrombin deficiency, and others, all of which are vital for normal blood clot formation.
Causes & Symptoms
Clinical Causes: Genetic mutations inherited from parents Autosomal recessive inheritance most commonly observed Mutations affecting genes responsible for specific clotting factors Rarely, acquired factors due to other medical conditions or treatments
Key Symptoms: Unexplained bleeding or bruising Nosebleeds that are difficult to control Bleeding gums Heavy or prolonged menstrual periods Bleeding after injuries or surgeries Internal bleeding, which can cause pain or swelling Bleeding into joints or muscles causing swelling and pain
Diagnostic & Treatment
Diagnosis Path: a comprehensive coagulation panel, specialized factor assays, and genetic testing to identify specific mutations responsible for the deficiency. Consulting with a hematologist is essential for accurate diagnosis and assessment of bleeding risk.
Treatment Protocols: Factor replacement therapy: Administering specific clotting factor concentrates during bleeding episodes or prior to surgical procedures. Blood transfusions in severe cases of bleeding. Cryoprecipitate infusions for fibrinogen deficiency. Medications like desmopressin (DDAVP) may help increase certain clotting factors temporarily. Preventive measures, including avoiding medications that impair clotting (like aspirin) and minimizing injury risk.
Clinical Advice & FAQs
Billing Guidance
Is D68.2 a billable ICD-10 code?
Yes, D68.2 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D68.2?
Clinical documentation must specify the nature of Hereditary deficiency of other clotting factors and any associated comorbidities for accurate reporting.
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