D68.1
Hereditary factor XI deficiency
Clinical Classification Guidelines
Inclusion Terms
- Hemophilia C
- Plasma thromboplastin antecedent [PTA] deficiency
- Rosenthal's disease
Medical Intelligence & Overview
Hereditary Factor XI deficiency, also known as Hemophilia C or Plasma thromboplastin antecedent deficiency, is a rare bleeding disorder caused by a deficiency of factor XI, a protein crucial for blood clotting. Unlike other forms of hemophilia, it tends to cause milder symptoms, which can vary widely among individuals. This condition is inherited, meaning it is passed down through families, and it primarily affects blood clotting, making it more difficult for the body to stop bleeding after an injury or surgery.
Causes & Symptoms
Clinical Causes: Genetic inheritance: The condition is inherited in an autosomal recessive pattern, which means an individual needs to inherit two copies of the defective gene (one from each parent) to have the disease. Family history: People with relatives who have bleeding disorders, particularly Hemophilia C, are at higher risk. Genetic mutations: Specific mutations in the F11 gene, which encodes for factor XI, lead to reduced or dysfunctional factor XI protein.
Key Symptoms: Excessive bleeding from minor cuts or injuries Bleeding following surgery or dental procedures Frequent or prolonged nosebleeds Heavy or prolonged menstrual bleeding Bleeding into joints or muscles (less common) Spontaneous bleeding without clear cause (rare)
Diagnostic & Treatment
Diagnosis Path: Diagnosis involves a combination of blood tests and family history analysis. Key steps include:
Treatment Protocols: Management of hereditary Factor XI deficiency varies based on the severity of symptoms. Common approaches include:
Clinical Advice & FAQs
Billing Guidance
Is D68.1 a billable ICD-10 code?
Yes, D68.1 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D68.1?
Clinical documentation must specify the nature of Hereditary factor XI deficiency and any associated comorbidities for accurate reporting.
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