D68.02
Von Willebrand disease, type 2
Clinical Classification Guidelines
Inclusion Terms
- Qualitative defects of von Willebrand factor
Medical Intelligence & Overview
Von Willebrand disease (VWD) is a bleeding disorder caused by a deficiency or dysfunction of von Willebrand factor (VWF), a protein essential for blood clotting. Type 2 VWD, specifically, involves qualitative defects in VWF, meaning the protein is present but does not work correctly. Recognized under ICD-10 code D68.02, this condition affects the body's ability to form stable blood clots, leading to increased bleeding episodes. It's one of the more common hereditary bleeding disorders and can range from mild to severe in clinical presentation.
Causes & Symptoms
Clinical Causes: Inherited genetic mutation affecting the production or structure of von Willebrand factor Autosomal dominant inheritance pattern, often passed from parent to child Mutations specific to qualitative defects where VWF is produced but malfunctioning Rare cases may involve spontaneous mutations with no family history
Key Symptoms: Frequent nosebleeds (epistaxis) Heavy or prolonged bleeding during cuts or injuries Bleeding gums Unusual bleeding after surgery or dental procedures Heavy menstrual periods (menorrhagia) Blood in urine or stool in severe cases Easy bruising and excessive bleeding after minor injuries
Diagnostic & Treatment
Diagnosis Path: Complete blood count (CBC) to evaluate overall blood health VWF antigen test to measure the amount of von Willebrand factor in blood Ristocetin cofactor activity test to assess VWF function Factor VIII activity test, as VWF stabilizes factor VIII Additional specialized tests to identify specific type and nature of VWF defect
Treatment Protocols: Desmopressin (DDAVP): a medication that stimulates release of VWF stored in blood vessel lining, suitable for some patients VWF concentrates: infusions of plasma-derived products containing von Willebrand factor and factor VIII Antifibrinolytic drugs: such as tranexamic acid or epsilon-aminocaproic acid to help stabilize blood clots Lifestyle adjustments: avoiding medications that increase bleeding risk (e.g., aspirin), and planning for prompt treatment of bleeding episodes Regular follow-up with hematologists for personalized management and monitoring
Clinical Advice & FAQs
Billing Guidance
Is D68.02 a billable ICD-10 code?
Yes, D68.02 is a specific, billable code that can be used to indicate a diagnosis for reimbursement purposes.
Documentation
How do I report D68.02?
Clinical documentation must specify the nature of Von Willebrand disease, type 2 and any associated comorbidities for accurate reporting.
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